Everything about ceesdekker.net
Everything about ceesdekker.net
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‘The second is nanopores, that is our oldest line of study and which has now led to DNA sequencers depending on nanopores. We pull personal DNA strands through a nanopore and can then read from the nucleotide sequence. Pretty lately, we even managed to study out a single protein for The 1st time applying This system. But this line of exploration is not merely about building resources, but additionally about real Organic issues.
It had been only during the nineties though, when nanotechnology experienced advanced into a amount in which one molecules might be manipulated, that the 1st experimental gadgets started to look.
[Laughs] ‘It was certainly a fantastic threat! At time, I was well knowledgeable that it could go Completely wrong Which I could turn into a lot less effective, but I just ignored that. Curiosity has normally been my strongest driving drive. And by chance it all labored out.’
2007, 1st genuine-time detection of strand exchange in homologous recombination by RecA; discovery of the low persistence length of finishes of microtubules; and fixed the system of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
‘In the beginning we checked out Organic methods by using a Actual physical view and acted on The idea with the applications we knew. It took a couple of years ahead of we begun working a lot more on the large Organic difficulties. I then began to call it nanobiology, a phrase that did not exist at time.
2011, very first in vitro measurements of transport across only one biomimetic nuclear pore elaborate; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
In 1993, being a youthful and keen associate professor at Delft University of Technological innovation, I'd initially targeted the investigation endeavours of my team on measuring the electrical conductance of a single conducting-polymer molecule. Inside of two decades, we experienced produced a device through which one wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced steel nanoelectrodes.
There was a person trouble though — we did not notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule amount, conducting polymers were being actually not this kind of fantastic conductors, which was fairly disappointing. We Hence broadened our check out to try to locate a lot more promising molecules.
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more not long ago his analysis has centered on learning chromatin framework and cell division with micro organism on chip, whilst he is likewise attempting to in the long run Develop artificial cells from The underside up.
Many new phenomena ended up identified, and he and his research group founded a leading posture In this particular field of exploration. Dekker and his study team found new ceesdekker.net physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the main to construct a transistor dependant on just one nanotube molecule.
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It absolutely was a very intriguing time, through which I received plenty of guidance from Delft College of Technologies, the place I had been a professor at some time, And that i began numerous collaborations with molecular biologists. That aided me master a lot.’